Background: Genetic research involving racial/ethnic populations has novel ethical implications for various stakeholders, but ethical acceptability among stakeholders regarding such research is not clear. Methods: As part of a multifaceted National Institute of Mental Health (NIMH)/National Human Genome Research Institute (NHGRI) funded survey, we used repeated-measures factorial multivariate analysis of variance (MANOVA) to compare the perspectives of institutional review board (IRB) chairs (n = 203), investigators (n = 183), and community members (n = 192) on the ethical acceptability of participating (...) in and reporting of psychiatric genetic research focused on racial/ethnic minority groups. Stakeholder views were assessed with two sets of three questions. Results: All stakeholder groups perceived participation in genetic studies focused on racial/ethnic groups as ethically acceptable and endorsed as ethical any decisions by racial/ethnic minorities to decline to participate in such studies if concerned about possible discrimination/stigmatization based on the study findings. Stakeholders disagreed considerably on the ethical acceptability of researchers or journal editors choosing not to publish genetic study results focused on racial/ethnic minority groups based on potential harm of the study findings. Conclusion: Findings show community and professional stakeholders support participation in genetic research focused on specific racial/ethnic groups but recognize that the results of such studies may contribute to discrimination or stigmatization. Stakeholders differed in their perspectives of investigators and editors in balancing ethical issues intrinsic to advancing science versus minimizing harm to potentially vulnerable populations. (shrink)

Weiss, Propen, and Reid gather a diverse group of scholars to analyze the growing obsolescence of the human-object dichotomy in today's world. In doing so, Design, Mediation, and the Posthuman brings together diverse disciplines to foster a dialog on significant technological issues pertinent to philosophy, rhetoric, aesthetics, and science.

Vaesen asks whether goal maintenance and planning ahead are critical for innovative tool use. We suggest that these aptitudes may have an evolutionary foundation in motor planning abilities that span all primate species. Anticipatory effects evidenced in the reaching behaviors of lemurs, tamarins, and rhesus monkeys similarly bear on the evolutionary origins of foresight as it pertains to tool use.

Vascular calcifications are the consequence of several pathological conditions such as atherosclerosis, diabetes, hypercholesterolemia and chronic renal insufficiency. They are associated with risks of amputation, ischemic heart disease, stroke and increased mortality. A growing body of evidence indicates that vascular smooth muscle cells (VSMCs) undergo chondrogenic commitment eventually leading to vascular calcification, by mechanisms similar to those governing ossification in the cartilage growth plate. Our knowledge of the formation of cartilage growth plate can therefore help us to understand why and (...) how arteries calcify and, consequently, develop new therapeutic strategies. Reciprocally, thorough consideration of the events leading to ectopic chondrocyte differentiation appears crucial to further increase our understanding of growth plate formation. In this context, we will review the effects of known or suspected factors that promote chondrogenic differentiation in growth plate and arteries. BioEssays 27:708–716, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In a recent target article, Buchbinder et al. (2024) advance moral stress as a complement to the more familiar, albeit contested, concept of moral distress. They are concerned that moral distress m...

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

L'eschatologie a marqué la théologie chrétienne du XXe siècle. Initiateur en ce domaine, R. Bultmann entreprend une herméneutique « existentiale » et « démythologisante » de la prédication apocalyptique de Jésus, mise en lumière par J. Weiss et A. Schweitzer : en Jésus Dieu prononce la parole définitive qui m'appelle aujourd'hui à la décision de foi et à l'existence authentique. La théologie apprend ainsi à parler de Dieu avec sens en parlant de l'homme. Avec J. Moltmann, le futur est (...) désenclavé du présent où le laissait Bultmann, et l'eschatologie se fait résolument christologique en même temps qu'historique ; mais le passage de la Théologie de l’espérance au Dieu crucifié pose le problème redoutable du lien entre l’horizon de l’espérance et l'histoire abandonnée à la souffrance. Pour J. Moingt, la résurrection, fondement de la christologie, permet de relire la vie de Jésus comme l’histoire de Dieu menant avec les hommes depuis la création le combat eschatologique de la vie contre la mort.La pensée eschatologique s’élabore aussi dans la ligne des théologiens de l'histoire. O. Cullmann fait du Christ le centre de l’histoire du salut, entre un « déjà là » et un « pas encore ». Avec plus d’ambition mais aussi d’ambiguïté, W. Pannenberg situe la résurrection de Jésus, en tant qu’événement historique, au regard de l'histoire universelle dont elle anticipe la fin. La pensée eschatologique ne laisse pas de travailler également d’autres théologies, davantage marquées par les problématiques traditionnelles.Twentieth century Christian theology has been marked by eschatology. R. Bultmann, initiator in this field, underlook an “existential” and “demythologising” hermeneutic of the apocalyptic preaching of Jesus, which had been brought. to light by J. Weiss and A. Schweitzer : in Jesus God pronounces the definitive word that calls me to a decision of faith and authentic existence today. Theology thus learns to speak of God with meaning by speaking of man. With J. Moltmann, the future is freed from present, where Bultmann had left it, and eschatology became resolutely Christological at the same time as historical. But the passage from the Theology of Hope to the Crucified God poses the difficult problem of the connection between the horizon of hope and history left to suffering. For J. Moingt, the resurrection, foundation of Christology, permits a rereading of the life of Jesus as the history of God, who, from the time of creation, leads humanity in the eschatological combat of life against death.Eschatological thought also develops in the direction of theologies of history. O. Cullmann makes Christ the center of the history of salvation, between an “already here” and a “not yet”. With greater ambition but also ambiguity, W Pannenberg places the resurrection of Jesus as a historical event, in comparison with universal history, of which it anticipates the end. Eschatological thought does not fail to also influence others theologies, more marked by traditional problematics. (shrink)

In his Ars grammatica Fl. Sosipater Charisius quotes long portions of text which he has taken over from books of other grammarians. One of these quotations starts at 246.18 and continues up to 289.17. At 246.19–252.31 we find a long argument in which Romanus offers a sort of introduction to the theory of the adverb. This introduction is a surprise to modern readers because it is written in a very rhetorical manner. I mention this because otherwise one cannot understand why (...) at 251.22ff. the author of a Latin treatise on grammar should quote from a Greek work on Aristotle's Categories by a certain Aquila. (shrink)

Millum and Bromwich provide a thorough and thoughtful analysis of what is required for sufficient informed consent, offering distinct conceptualizations of the ethical requirements of disclo...